Chromosomal mosaicism goes global

Sex Chromosomal Mosaicism

Morphological abnormalities of the X chromosome are well documented and have been extensively reviewed and discussed by Ferguson-Smith (1965). They include isochromosome of the long arm, deletions of the long and short arms, ring chromosomes, and chromosomal fragments. Other types of abnormality are rare. Engel and Forbes (1965) described a chromatin negative girl (Patient No. 27) with a mosaic...

Turner Syndrome and Sex Chromosomal Mosaicism

Chromosomal mosaicism in neural stem cells.

Neural stem and progenitor cells (referred to here as NSCs), located in the proliferative zones of embryonic brains, can be seen undergoing mitosis at the ventricular surface. Mitotic NSCs can be arrested in metaphase and chromosome "spreads" produced to reveal their chromosomal complement. Studies in mice and humans have revealed a prominent developmental presence of aneuploid NSCs, whereas ot...

ISBER Goes Global.

ISBER’s vision is to be the leading global forum for promoting harmonized high quality standards, ethical principles, and innovation in the science and management of biorepositories. Our mission is to create opportunities for sharing ideas and innovations in biobanking and for harmonization of scientific, technical, legal, and ethical approaches to evolving challenges in biobanking. For those r...

Death Goes Global:

We present a case study—the U.S. death care industry—that largely violates the assumptions of foreign direction investment (FDI) theory. Based on this anomaly, we develop several questions to help us understand whether this is a unique case, whether other anomalies may also exist, and what this might mean for FDI theory. We hope to generate discussion to help us answer these questions.